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Respiratory issues are another side effect common with opioid medications. As depressant drugs, they can slow a person’s breathing rate, even to the point of death. UF’s experiments showed LKT did not induce respiratory depression, which reduces the likelihood of an opioid-like overdose death.
“What we learned was that across a wide dosing range — all the way up to the average human equivalence dose that people use — kratom was very safe and did not affect respiration or coordination,” McCurdy said. “It looks to be a very safe and efficacious product in the model we used and in the more traditional-inspired form of medication that we used.”
While federal regulators evaluate the safety of the plant, McCurdy and colleagues are contributing data through multiple kratom studies. The National Institute on Drug Abuse has awarded UF two multimillion-dollar grants to examine kratom’s individual alkaloids and investigate the different ways it is consumed.
An online version of the study “Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence” was published in the journal Drug and Alcohol Dependence. Lisa Wilson, a graduate student in the UF College of Pharmacy, served as lead author of the study, while McCurdy and McLaughlin were co-authors.
Source : Pharmacy.ufl.edu | Kratom Study