What is Kratom?
For those that don’t know, kratom is powdered leaf from the Mitragyna speciosa tree which grows wild in Indonesia. The leaves are dried, ground and imported into the USA to be resold.
The naturally-occurring alkaloids in the kratom leaf partially bind to our opioid receptors. This offers both pain relief and mental stimulation when consumed.
What is a Potentiator?
To potentiate something means to increase the potency of that thing, especially when referring to medicine.
Today the term “kratom potentiator” has become a blanket statement which means any substance that can be taken to increase the effect kratom has on an individual.
But technically this isn’t correct, and not knowing the difference can affect your desired outcome! That’s why we’ve divided it into the following subcategories:
1. Kratom Potentiators – Substances that increase the available strength of the kratom itself.
2. Kratom Bioavailability Enhancers – Substances that increase the percentage amount your body absorbs from the kratom. These increase the effect kratom has by increasing the percentage of alkaloids your body absorbs from the amount you already take.
3. Kratom Tolerance Reducers – Substances that reduce a user’s tolerance to kratom’s effects. These can indirectly increase the effect of kratom you feel by reducing your accumulated tolerance to it.
Depending on which subcategory the substance falls under, you would likely want to take it at different times and frequencies. Typically, (1) potentiators are taken with kratom, (2) bioavailability enhancers are taken before you take kratom, and (3) tolerance reducers are taken at other times or on days when you don’t consume kratom.
However, because many of the substances commonly called “potentiators” don’t fall into any of these 3 categories, we’ve defined a fourth type just for them:
4.Kratom Synergizers – Substances that have their own effect on the mind and/or body, and that are believed to increase the desirable effects of kratom through synergy alone. Any substance under this type does not directly increase the strength of kratom. Instead, its own effects are thought to go well when combined with the effects of kratom.
Since the effects of synergizers are to be felt at the same time as the effects of kratom, they’re usually taken together with kratom (unless there is a delay between the consumption of the substance and the time it takes for its effects to “kick in”).
Why Would Someone Want to Potentiate their Kratom Dosage?
Some reasons to increase your kratom’s strength are:
To get more out of less
Using less kratom to get a larger effect means that you will waste less, thus saving money.
Consider this hypothetical situation: You take kratom daily for pain relief. This morning you go to take your kratom but realize you are very low on powder. Instead of running out to buy more locally from a place you don’t know or trust, you could try potentiating with lower amounts. This could allow you enough time to wait for your next purchase to arrive if you buy online.
To Reduce tolerance
Users who take kratom regularly may want to lower their tolerance, thereby decreasing the overall amount they must take to achieve the same effect.
To feel a stronger effect
Users may not be satisfied with the strength of the kratom that they take, and thus potentiating their dosage could bring the effect up to satisfactory levels.
To increase the duration of effect
Instead of redosing, users may be able to use a substance that slows the removal of kratom alkaloids from the body, thereby increasing the time before it wears off.
To Swallow less Powder at one time
Using regular kratom powder requires you to consume from 1 to 5 grams at a time. But kratom tastes like dirt and tree leaves. That’s why kratom users look for better ways to consume it.
Is it Safe to Potentiate Kratom?
Although a small number of cases have been reported involving deaths with combined drug intake and kratom use, not one cause of death has ever been linked to kratom alone, or kratom combined with any of the substances listed here.
That said, we’re not doctors, and none of this is medical advice… nor should it be considered as such. We simply want to provide you with a full wealth of information, unlike most sources about how to potentiate kratom powder.
It’s our personal opinion that our bodies work the way they do for a reason. So long as we are healthy individuals with healthy habits who eat healthy foods and take healthy supplements… nature and our bodies should do the rest. But that’s not to say we can’t improve how our bodies absorb nutrients naturally.
However, we also believe that taking unnatural chemicals/drugs for the sole purpose of stimulating a stronger effect from a natural product (like kratom) seems counterproductive. But since the internet is full of recommendations like this, we will include every one we've found and discuss it with research and user reports.
What are the Best Kratom Potentiators Out there?
With a quick Google search, you can find all sorts of advice for potentiating your kratom doses. But this stuff isn’t some sort of voodoo magic… it should be based on the most current scientific research.
Unfortunately, much of the available data has no evidence to support it and is oftentimes just plain wrong.
For example, some sources recommend taking anti-acids before ingesting kratom.
This may seem like a good idea because science suggests putting your body into a more alkaline state helps absorption. However, although antacids produce an alkaline environment in the stomach, they ironically contribute to metabolic acidosis.
Meanwhile, consuming citrus and other acids actually put us in a more alkaline state, and thus may do better to increase the bioavailability of kratom.
There being so much conflicting data on the internet can be confusing. And considering the placebo cure rate in medical trials ranges from 15% to 79%, many of the suggestions out there could be due to the placebo effect alone!
This is one of the many reasons why we can’t be 100% sure that any kratom potentiators actually work. All we can do is present the current data available and let you decide for yourself what may or may not be useful.
List of Kratom Potentiators
The following is an alphabetical list we compiled of all the “kratom potentiators” that can be found across the internet. Because of this, we can’t speak to the safety or efficacy of any of them.
We will list the substance, the suggested reasoning for why it works, any evidence or user experience available, and a special “crapometer” rating from 1 to 5, with 1 being “may actually work” and 5 being “pure crap.”