How long I should wait between Kratom doses?

As the popularity of kratom soars throughout the Western World, more are learning about the effects and benefits of this natural herbal supplement. However, like all things, moderation is key. Used too much, even the best things lose their charm. This article explores the best way to balance kratom doses by reducing the likelihood of tolerance and side effects.

How long I should wait between Kratom doses?​

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Spacing Out Kratom Doses

There are two main reasons for spacing out kratom doses: ensuring consistent effects daily and to reduce long-term dependency. Since the half-life of mitragynine is about 24 hours, this means that only half the mitragynine is metabolized. By taking a dose every 12 hours, this maintains a consistent dose of kratom alkaloids in the bloodstream.

Avoiding Tolerance

Spacing out your doses also decreases the likelihood of tolerance. With daily kratom use, it is only natural for the body to build up a tolerance. As this happens, users find that they will require increasingly higher doses of kratom. Additionally, the effects become less apparent and enjoyable.

For many daily kratom users, the mood and energy boosting effects are the first to wear down with time. Not only that, the duration also the effects last dwindle, and users may even feel negative effects such as lethargy, fogginess, and fatigue. Comparatively, users who space out their doses to only take kratom several times a week continue to enjoy the best of kratom.

Kratom effects also decrease throughout the day. This is evidenced by the agreement that the first kratom dose of the day tends to be the longest lasting and strongest. As the day weighs on, subsequent kratom doses are no longer as effective and higher doses are required. Therefore, it is no surprise that users take increasingly larger doses of kratom.

One of the best solutions is to set a schedule to take kratom. While it may seem overkill, this schedule is a lifeline for many successful kratom users. The schedule does not have to be rigid. Instead, all that is required is to set a certain amount of time between kratom doses.

Duration Between Kratom Doses

The duration between kratom doses depends on the user and the effects desired. Users who use kratom daily should try to space out their doses by about 12 hours if possible. After a week or so, the kratom levels in the system are now consistent.

Users who are not using kratom daily can enjoy a shorter time frame of about 6 hours between kratom doses. These users should aim to avoid using kratom for about one to two days after their “kratom day” as this can help avoid the development of tolerance.

For users who are using kratom to manage opiate withdrawal symptoms, try to space out the use of kratom as far as possible. This duration differs for each individual depending on the severity of opiate addiction and symptoms. It could be as short as 4 hours or more. The goal in this situation is to space it out as much as possible. With time, this duration gradually increases to the point the user can be weaned off opioids and kratom completely.

Spacing Kratom Doses Based On Need

Users who are taking kratom based on a specific need should still stick to the general rule of stretching out the dose as much as possible to decrease tolerance. Bear in mind that all individuals are unique, and therefore, have different needs.

Users who have a medical condition should always consult a medical professional before taking kratom or increasing their dose of kratom. Here is a general idea of what to expect when spacing kratom doses based on a specific need:


Users who take kratom for pain usually require moderate to larger doses of potent kratom. When taken regularly, the body develops tolerance quickly. It is recommended that users wait at least six hours until the next dose. Since pain can be debilitating, it is understandable to reach for the next dose earlier than scheduled.

To avoid breakthrough pain, users can use a smaller dosage to reduce the time gap or to not completely rely on kratom for pain relief. Over the counter pain medication may be able to provide some relief to bridge the gap between two kratom doses.


Anxiety is the devil when it is uncontrolled. Users who use kratom to harness their anxiety and keep negative thoughts at bay should wait at leeast five to six hours between doses. If doable, space out the doses as much as possible, use the lowest dose possible, and switch between kratom strains regularly.


Users who use kratom for better focus and mental clarity can do with low doses of stimulating strains of kratom. Although six hours is the minimum between doses, wait as long as possible and take the next dose about half an hour before it is required instead. When taken too much or too often, it can be counterproductive and result in headaches and nausea.

Mood Elevation

With recreational use, enforce discipline and try to stick to only one dose a day. Taking a second dose for its euphoric effects is also hardly beneficial as the second dose will no longer provide as significant a mood boost.

Related: Kratom Dosage; Properly Measuring Your Kratom Powder

Tips & Tricks On Spacing Out Kratom Doses

Here are some tips and tricks that can help users space out their kratom doses:


Kratom potentiators can be very helpful in spacing out kratom doses as they help to enhance or improve kratom effects. Some potentiators work by stopping your body break down kratom. This may not be a good thing as it can result in the body building a faster tolerance compared to normal. Some of the best kratom potentiators are:

  • Citrus Fruit Juice

A great potentiator, the zing and tang from citrus also hides kratom’s bitterness. It works as the citrus juice contains enzymes that enhance the effects of alkaloids.

  • Turmeric

This popular spice is an excellent anti-inflammatory. It works as a kratom potentiator by reducing the metabolization of kratom.

  • Chamomile

Chamomile works marvelously with red vein strains as it maximizes the sedative and relaxing effects.

  • Watercress

This plant works by slowing down the metabolization of kratom alkaloids. Take it 45 minutes before taking kratom.

  • Cat’s Claw

A plant also packed with alkaloids, it enhances the potency and efficiency of kratom by speeding up kratom’s effects.

  • Caffeine

This kratom potentiator is no stranger to most individuals. Mix some kratom powder into a caffeinated beverage and see it work its magic.

Other Supplements

Since the body builds up tolerance to any substance over time, alternating the use of kratom may be helpful. This can be done by adding in different herbs, supplements, and stretching out the time between kratom doses as much as possible.

Users who are taking kratom for energy can try options such as guarana, guayusa, yerba mate, and coffee while those looking for a sleep aid may benefit from kava, cannabis, damiana, and passionflower. To improve focus, supplements such as ginseng, bacopa, ashwagandha, and rhodiola may be beneficial.


Kratom users are always recommended to keep a journal as it helps to keep track of all the doses taken along with the effects experienced. This is especially useful for new kratom users as it helps them to get a sense of what is working and what is not. Most who keep a kratom journal often use smaller doses as they are able to find the smallest dose that produces their desired effects.


Some users have also found that using different strains regularly slows down tolerance tremendously as users who continuously use the same strain allows the body to build up tolerance to the same alkaloid profile over time. Another great method is to take a gap from kratom for a week after using it for six to eight weeks.


Kratom is most commonly available as kratom powder or kratom capsules. These are the two best forms of kratom to take to decrease the chances of developing tolerance. Avoid extracts, tinctures, and extracts as these forms of kratom are enhanced, making it hard for users to control thee dose they are taking.

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What Happens When Users Take Kratom Too Quickly?

As mentioned previously, taking too much too often can cause the body to build up a tolerance quickly. When tolerance occurs, users will use increasingly higher doses of kratom which can lead to dependence. It can also cause a host of nasty side effects such as nausea, vomiting, dry mouth, constipation, headaches, dizziness, irritability, and more.


Kratom is an amazing plant that shows amazing promise for a wide variety of purposes. However, users should maintain strict discipline regarding dosing so as not to experience tolerance or dependence.

Generally, users should space out their kratom doses as much as possible, ideally at least 12 hours as there are many tips and tricks that can stretch out the effects of kratom. However, this may not be possible due to therapeutic needs where a duration of at least 6 hours is acceptable.



The above article is a repost. Please refer to the source provided to go to the original article., it’s holding company, and it’s owners do not endorse any published content provided herein. strongly recommends following FDA guidelines regarding Kratom. Please refer to the following link for further information.

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